Reposição de testosterona em mulheres

Quando a mulher realmente vai precisar repor testosterona? Até que ponto isso é necessário ou saudável?

Artigos citados:
Bhasin S. Female androgen deficiency syndrome–an unproven hypothesis. J Clin Endocrinol Metab. 2005 Aug;90(8):4970-2.Handelsman DJ, Hirschberg AL, Bermon S. Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance. Endocr Rev. 2018 Oct 1;39(5):803-829. doi: 10.1210/er.2018-00020.Herold & Fitzgerald (2003). Immunoassays for testosterone in women: better than a guess? Clin Chem. 2003 Aug;49(8):1250-1.Kvorning T, Andersen M, Brixen K, Madsen K. Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1325-32. Epub 2006 Jul 25.Miller KK Rosner W, Lee H, Hier J, Sesmilo G, Schoenfeld D, Neubauer G, Klibanski A. Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods. J Clin Endocrinol Metab. 2004 Feb;89(2):525-33.Smith GI, Yoshino J, Reeds DN, Bradley D, Burrows RE, Heisey HD, Moseley AC, Mittendorfer B. Testosterone and progesterone, but not estradiol, stimulate muscle protein synthesis in postmenopausal women. J Clin Endocrinol Metab. 2014 Jan;99(1):256-65. doi: 10.1210/jc.2013-2835. Epub 2013 Dec 20.